Klinefelter syndrome is the result of male hypogonadism.  Hypo means under and gonad refers to the testes in males and the ovaries in females.  A testicle in a typical XXY is usually far too small and atrophied to produce sufficient amounts of testosterone.  Therefore, male hypogonadism is the testes not producing sufficient amounts of testosterone, which leads to the development of any number of symptoms that collectively have come to be known as Klinefelter syndrome.

Further Reading and Resources:

AACE clinical practice guidelines.  This is a .PDF article that will open when the link is clicked. Easily the best site on the net for hypogonadism.

Androgen Insensitivity Syndrome Support Group (AISSG)

Hypogonadism2 is the best e-mail list of its kind that I have found. Expect a LOT of well-informed expert mail. The list is very good for anyone who identifies as male and wishes to explore, understand, and use Tesosterone Replacement Therapy. To subscribe, please click here.

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